Chondroitin sulfate is an acidic mucopolysaccharide extracted from healthy domestic animal cartilage or shark cartilage, mainly composed of chondroitin sulfate A, C and other types of sulfuric acid Chondroitin is widely found in animal cartilage, laryngeal bone, nasal bone, and also in bone tendon, ligament, skin, cornea and other tissues. Chondroitin sulfate exists mainly in the form of chondroitin sulfate sodium salt. Chondroitin sulfate is mainly composed of sodium sulfate sulfate copolymerized by N-acetylgalactosamine (2-acetamide-2-deoxy-β-D-galactopyranosine) and D-glucuronic acid. Alternately linked by β-1,4 and β-1,3 glycosidic bonds.
◆ Participate in making bones - bones are made of calcium and phosphorus. However, building bones requires amino acids and vitamin D. Chondroitin sulfate plays an important role in transporting or supporting materials to form bones during bone formation.
◆ To maintain the smoothness of joints - Chondroitin sulfate and hyaluronic acid are the main components of cartilage (27-43%) that mostly exist in joints, giving cartilage elasticity and smoothness. In addition, it is also related to the maintenance of elasticity of the ligaments or tendons that surround the joint. Hyaluronic acid is the main component of synovial fluid, and both chondroitin sulfate and hyaluronic acid can promote joint smoothness.
In terms of biomedical applications, as an orthopaedic drug for the treatment of arthritis, it has become a research hotspot for chondroitin due to its recognized efficacy. Similarly, chondroitin is also used in tissue engineering, ophthalmology and the treatment of cardiovascular diseases; Specifically, chondroitin sulfate is mainly used to prevent coronary heart disease, angina pectoris, myocardial infarction, coronary atherosclerosis, myocardial ischemia, prevent the formation of atherosclerosis, and treat neuralgia, neuropathic migraine, arthralgia, and joint pain. inflammation.