Focusfreda's national invention patent has been approved; its green manufacturing process addresses the key industrialization challenges associated with ultra-low-molecular-weight hyaluronic acid production.
Recently, the invention patent titled "Method for Preparing Ultra-Low Molecular Weight Hyaluronic Acid and Its Derivatives from Fermentation Broth," independently applied for by Focusfreda, was officially granted authorization by the National Intellectual Property Administration (Patent No. ZL 2025 1 1907331.8). This patent focuses on the field of bioengineering and, by leveraging fermentation broth as the starting material, establishes a key technological pathway for the efficient and sustainable production of ultra-low molecular weight hyaluronic acid. The granting of this patent not only demonstrates the company's strong R&D capabilities but also represents another significant core technological achievement by Focusfreda in the field of sustainable hyaluronic acid manufacturing.
Hyaluronic acid—commonly known as hyaluronic acid (HA)—does not possess only the property of "moisturizing." HA with different molecular weights exhibits distinct physiological functions and application potential. High-molecular-weight hyaluronic acid primarily serves moisturizing, lubricating, and barrier-forming roles; in contrast, ultra-low-molecular-weight hyaluronic acid, owing to its smaller molecular size, demonstrates unique biological activities—including strong ability to penetrate the skin barrier, excellent immunomodulatory properties, capacity to promote angiogenesis, and antioxidant effects—and can also be utilized as a drug delivery vehicle. Consequently, ultra-low-molecular-weight hyaluronic acid and hyaluronic acid oligosaccharides hold broad application prospects in fields such as high-end cosmetics, functional foods, and pharmaceuticals.
In the state-of-the-art industry practices for preparing ultra-low molecular weight hyaluronic acid from fermentation broth derived from Streptococcus suis fermentation, the primary approach involves degrading high-molecular-weight hyaluronic acid raw materials—obtained after preliminary purification and refinement of the fermented broth—through either chemical or physical degradation methods. However, these conventional methods often suffer from significant drawbacks, such as high ethanol consumption and high energy consumption; furthermore, it is challenging to ensure the stability of both the purity and yield of the resulting ultra-low molecular weight hyaluronic acid or its derivatives. Addressing these limitations of existing technologies, the present invention provides a method for preparing ultra-low molecular weight hyaluronic acid and its derivatives starting from fermentation broth via filtration, purification, enzymatic hydrolysis, and post-treatment processes. This method significantly reduces ethanol consumption, lowers costs and enhances efficiency, enables more precise control of molecular weight and greater batch consistency, and thereby provides a solid guarantee for product quality and overall cost-effectiveness.
The successful grant of this patent serves as strong evidence of Focusfreda's commitment to independent innovation and its deep dedication to the field of biomanufacturing. Against the backdrop of the "Dual Carbon" strategy, green and low-carbon practices have become a central theme for the high-quality development of the biomaterials industry. Through core process innovation, this patent reduces the use of ethanol-based organic solvents at the production source, lowers the energy consumption and volatile pollutant emissions associated with the solvent recovery process, minimizes the carbon footprint across the production lifecycle, and integrates low-carbon principles throughout the entire raw material production process.
Moving forward, the company will continue to drive the translation of patented technological achievements into real-world production applications, prioritizing green manufacturing and low-carbon production practices within its R&D efforts, and facilitate the deployment of ultra-low molecular weight hyaluronic acid across a diverse range of applications—including cosmetics and skincare, oral health, and pharmaceutical delivery systems—thereby leveraging technological innovation to propel the hyaluronic acid industry toward an upgrade and sustainable development path.
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