Good news! FocusFreda once again obtained an invention patent, which provides a new idea for the large-scale preparation of specific molecular weight hyaluronic acid
Recently, the invention patent jointly applied by FocusFreda and Jiangnan University was authorized by the State Intellectual Property Office of China, "A kind of hyaluronic acid lyase and its recombinant bacteria and application". The grant of this patent marks a new breakthrough for FocusFreda in the technical field of preparing sodium hyaluronate with specific molecular weight.
As an important glycosaminoglycan, hyaluronic acid is widely used in medicine, cosmetics, food and other fields because of its unique hydrophilicity, viscoelasticity and biocompatibility. However, the degradation of hyaluronic acid in the process of preparation has been a big problem for researchers.
The patented technology can effectively reduce the difficulty of preparing and degrading hyaluronic acid. Traditional physical degradation methods are difficult to degrade hyaluronic acid to less than 10 kDa, and chemical degradation methods to prepare hyaluronic acid oligosaccharides require harsh reaction conditions, but in contrast, the use of enzyme degradation of hyaluronic acid preparation is not the same. The invention provides a hyaluronic acid lyase and a recombinant strain expressing hyaluronic acid lyase and its application, which can solve the shortcomings of the traditional technology. Using this enzymatic degradation method to degrade hyaluronic acid with large molecular weight to small molecular hyaluronic acid has the advantages of environmental protection, rapid reaction and mild conditions, and the recombinant bacteria can produce a large amount of hyaluronic acid lyase in a short time, which provides a possibility for large-scale production.
The acquisition of the invention patent provides a new solution for the degradation and application of hyaluronic acid, and provides a new idea and method for the large-scale preparation of specific molecular weight hyaluronic acid for the hyaluronic acid industry. In the future development, FocusFreda will continue to be committed to the research and innovation in the field of hyaluronic acid and make greater contributions to the cause of human health.